Comparative effects of different phenothiazine photosensitizers on experimental periodontitis treatment

The aim of the present study was to compare effects phenothiazine photosensitizers methylene blue (MB), toluidine blue-O (TBO) and butyl (BuTB) in antimicrobial photodynamic therapy (aPDT), as adjuvant scaling root planing (SRP) treatment experimental periodontitis (EP) rats. 120 Wistar rats underwent ligation around lower left molar. After seven days, ligature removed. animals were separated into following groups (n = 15): EP, no treatment; SRP, SRP irrigation with saline solution; MB, deposition MB; TBO, TBO; BuTB, BuTB; MB-aPDT, aPDT TBO-aPDT, TBO and; BuTB-aPDT, BuTB. session performed after photosensitizer irradiation a diode laser (DL; InGaAlP, 660 nm, 40 mW, 60 s, 2.4 J). Histological histometric analysis performed. BuTB-aPDT group had lesser extent inflammatory process compared MB at all periods (p < 0.05). At 15 treated greater bone tissue structure than EP 0.05) BuTB showed Alveolar Bone Loss (ABL) TBO-aPDT 30 days using proved be that most favored reduction infiltrate furcation area ABL.